Why the study?
Does myocardial infarction reduce ventricular performance and Na+-K+ ATPase activity in Wistar rats?
Population
Wistar rats (8-10 per group)
Comparison
Left coronary artery ligation vs Sham-operation
Design
Preclinical
Follow-up
30 days
Authors
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Reduced post-MI inotropy in rats does not alter clinical practice; leaves open Na+-K+ ATPase as therapeutic target in human HF.
Does myocardial infarction reduce ventricular performance and Na+-K+ ATPase activity in Wistar rats?
Myocardial infarction in rats leads to early and late reductions in ventricular Na+-K+ ATPase activity and contractility, contributing to ventricular dysfunction.
Stefanon et al. (2009) studied this question.
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