Key result
Left coronary artery ligation in rats resulted in a significantly depressed inotropic response to calcium and isoprenaline compared to controls throughout the 14-day observation period.
Population
Albino rats of either sex, 180-250 g (n=56 total: 24 infarcted, 26 sham, 6 normal controls)
Comparison
Left coronary artery ligation vs Sham operation or normal controls
Design
Preclinical
Follow-up
up to 14 days (assessed at 1, 3, 7, or 14 days)
Authors
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May signal early post-MI inotropic impairment in rats; leaves open human translation and clinical relevance.
In a rat model of myocardial infarction, hypertrophy of the surviving myocardium does not improve left ventricular systolic function or inotropic response during the first two weeks.
Mill et al. (1990) studied Left ventricular infarction (n=56). Left coronary artery ligation vs. Sham operation or normal controls was evaluated on Left ventricular systolic function (isovolumetric systolic pressure). Left coronary artery ligation in rats resulted in a significantly depressed inotropic response to calcium and isoprenaline compared to controls throughout the 14-day observation period.
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