April 1, 1979Circulation Research
Myocardial infarct size and ventricular function in rats.
Why the study?
Does the size of myocardial infarction determine the degree of ventricular function impairment in a rat model?
Population
Rats 21 days after left coronary artery occlusion
Comparison
Left coronary artery occlusion to induce… vs Sham-operated, noninfarcted rats
Design
Preclinical
Follow-up
21 days
Authors
Discussion
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Implication
Supports graded LV dysfunction by infarct size in rats; leaves open translation to human post-MI risk stratification.
Key Points
- To explore how infarct size influences ventricular performance in a rat model after left coronary artery occlusion.
- Performed hemodynamic studies in rats 21 days post left coronary artery occlusion.
- Assessed baseline hemodynamics and peak cardiac performance under anesthesia.
- Measured infarct size via histological planimetry of the left ventricle.
- Rats with small infarctions (4-30%) showed no impairment in hemodynamics or pumping ability.
- Moderate infarctions (31-46%) displayed normal baseline hemodynamics but reduced peak flow and developed pressure.
- Infarctions > 46% resulted in congestive heart failure, marked by elevated filling pressures and reduced cardiac output.
Structured PICO
Does the size of myocardial infarction determine the degree of ventricular function impairment in a rat model?
P
Population
Rats 21 days after left coronary artery occlusion
I
Intervention
Left coronary artery occlusion to induce myocardial infarction of varying sizes
C
Comparator
Sham-operated, noninfarcted rats
O
Outcome
Ventricular performance assessed by baseline hemodynamics and stressed performance (peak cardiac output, stroke volume, peak left ventricular developed pressure)surrogate
In a rat model of healed myocardial infarction, the degree of left ventricular dysfunction is directly proportional to the size of the infarct.
Cite This Study
Pfeffer et al. (1979) studied this question.