Key result
Echocardiography in rats 4 weeks post-myocardial infarction detected significant increases in LV internal diastolic diameter (7.33 vs 5.91 mm; P<0.001) compared with sham-operated rats.
Why the study?
Does two dimensional guided M-mode echocardiography accurately assess left ventricular geometry and function following moderate size myocardial infarction in rats?
Does two dimensional guided M-mode echocardiography accurately assess left ventricular geometry and function following moderate size myocardial infarction in rats?
Absolute Event Rate: 7.33% vs 5.91%
p-value: p=<0.001
Transthoracic echocardiography is a valid noninvasive technique to assess postinfarction remodeling and systolic function in a rat model of moderate size myocardial infarction.
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Rat MI model shows LV dilation; confirms remodeling but leaves open human translation.
Burrell et al. (1996) studied Myocardial infarction (n=20). Myocardial infarction (left coronary artery ligation) vs. Sham operation was evaluated on Left ventricular internal diastolic diameter (p=<0.001). Echocardiography in rats 4 weeks post-myocardial infarction detected significant increases in LV internal diastolic diameter (7.33 vs 5.91 mm; P<0.001) compared with sham-operated rats.
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