Key result
Echocardiography in rats 4 weeks post-myocardial infarction detected significant increases in LV internal diastolic diameter (7.33 vs 5.91 mm; P<0.001) compared with sham-operated rats.
Why the study?
Does two dimensional guided M-mode echocardiography accurately assess left ventricular geometry and function following moderate size myocardial infarction in rats?
Population
Rats with moderate size myocardial infarction induced by left coronary artery ligation and sham operated rats
Comparison
Two dimensional guided M-mode echocardiography vs Sham operation and quantitative histological…
Design
Preclinical
Follow-up
4 weeks
Authors
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Rat MI model shows LV dilation; confirms remodeling but leaves open human translation.
Does two dimensional guided M-mode echocardiography accurately assess left ventricular geometry and function following moderate size myocardial infarction in rats?
Absolute Event Rate: 7.33% vs 5.91%
p-value: p=<0.001
Transthoracic echocardiography is a valid noninvasive technique to assess postinfarction remodeling and systolic function in a rat model of moderate size myocardial infarction.
Burrell et al. (1996) studied Myocardial infarction (n=20). Myocardial infarction (left coronary artery ligation) vs. Sham operation was evaluated on Left ventricular internal diastolic diameter (p=<0.001). Echocardiography in rats 4 weeks post-myocardial infarction detected significant increases in LV internal diastolic diameter (7.33 vs 5.91 mm; P<0.001) compared with sham-operated rats.
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