Key result
Serial echocardiography in mice with induced myocardial infarction demonstrated progressive LV dilatation and decline in fractional shortening over 9 weeks compared to sham-operated mice.
Population
C57 mice (n=32; 22 MI, 10 sham)
Comparison
Left coronary artery occlusion to induce… vs Sham-operation
Design
Preclinical
Follow-up
9 weeks
Authors
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Supports serial echocardiography for tracking post-MI remodeling in murine models; extends preclinical tools while leaving clinical translation open.
p-value: p=<0.01
Serial echocardiography reliably tracks time-dependent left ventricular remodeling and dysfunction in a murine model of myocardial infarction.
Xuemei Gao (2000) studied Myocardial infarction (n=32). Left coronary artery occlusion (induced MI) vs. Sham-operation was evaluated on Left ventricular dimensions (LVEDd, LVESd), fractional shortening (FS), and hemodynamics (p=<0.01). Serial echocardiography in mice with induced myocardial infarction demonstrated progressive LV dilatation and decline in fractional shortening over 9 weeks compared to sham-operated mice.
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