Population
Normal C57BL/6J mice (n=43)
Comparison
Left coronary ligation to induce myocardial… vs Sham procedure
Design
Preclinical
Follow-up
6 weeks
Key result
Left coronary ligation in mice induced significant ventricular remodeling at 6 weeks, including increased LV mass-to-body weight ratio and LV volumes compared to sham.
Authors
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Enables future transgenic studies of post-MI remodeling; leaves open clinical translation.
A mouse model of myocardial infarction via left coronary ligation successfully demonstrates quantifiable ventricular remodeling, providing a feasible model for future transgenic studies.
Patten et al. (1998) studied Myocardial infarction (n=43). Left coronary ligation vs. Sham procedure was evaluated on Ventricular remodeling (echocardiographic and hemodynamic parameters). Left coronary ligation in mice induced significant ventricular remodeling at 6 weeks, including increased LV mass-to-body weight ratio and LV volumes compared to sham.