Key result
Left anterior descending coronary artery ligation in mice resulted in marked left ventricular remodeling, increasing LV internal apical diameter from 2.82 mm at baseline to 3.49 mm at 7 days.
Absolute Event Rate: 3.49% vs 2.82%
p-value: p=<0.001
This study validates an optimized echocardiographic protocol, including long-axis FAC% and Tei Index, for accurate long-term monitoring of left ventricular remodeling and function in a mouse model of myocardial infarction.
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Validates optimized echo parameters for serial LV monitoring in murine MI models; leaves open translation to clinical post-infarct assessment.
Benavides et al. (2012) studied Myocardial Infarction (n=31). Left anterior descending coronary artery ligation vs. Baseline measurements was evaluated on Left ventricular internal apical diameter at 7 days (p=<0.001). Left anterior descending coronary artery ligation in mice resulted in marked left ventricular remodeling, increasing LV internal apical diameter from 2.82 mm at baseline to 3.49 mm at 7 days.
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