Why the study?
Does two-dimensional echo/Doppler accurately assess left ventricular damage compared to histology in rats with myocardial infarction?
Population
Female Wistar rats subjected to myocardial infarction via left main coronary artery ligation or sham…
Comparison
Two-dimensional echocardiographic/Doppler… vs Postmortem histological assessment and…
Design
Preclinical
Follow-up
minimum of six weeks
Key result
Non-invasive two-dimensional echocardiographic/Doppler measurements significantly correlated with histological determination of infarct size in rats (r = 0.84, p < 0.01).
Authors
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Supports echocardiographic surrogate for infarct size in rat models; leaves open translation to clinical settings.
Does two-dimensional echo/Doppler accurately assess left ventricular damage compared to histology in rats with myocardial infarction?
Effect estimate: r = 0.84
p-value: p=< 0.01
Two-dimensional echocardiography and Doppler techniques provide an accurate, non-invasive method to estimate left ventricular damage and infarct size in rat models of myocardial infarction.
Baily et al. (1993) studied Myocardial infarction (n=25). Two dimensional echocardiographic/Doppler techniques vs. Postmortem histological assessment was evaluated on Correlation between non-invasive echo/Doppler measurements of left ventricular damage and histological determination of infarct size (r = 0.84, p=< 0.01). Non-invasive two-dimensional echocardiographic/Doppler measurements significantly correlated with histological determination of infarct size in rats (r = 0.84, p < 0.01).