Why the study?
Do echocardiographic assessments using WMSI and MPI correlate with invasive indexes of LV function in a rat model of myocardial infarction?
Population
29 male Wistar rats undergoing left coronary artery ligation or sham operation
Comparison
Echocardiographic assessment using 13-segment… vs Invasive indexes obtained using a high-fidelity…
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports WMSI and MPI as surrogates for invasive LV indexes in rat MI models; leaves open human translation.
Do echocardiographic assessments using WMSI and MPI correlate with invasive indexes of LV function in a rat model of myocardial infarction?
WMSI and MPI are valid and reproducible echocardiographic indexes of global LV function in the rat myocardial infarction model.
Morgan et al. (2004) studied this question.