What question did this study set out to answer?

To determine the feasibility and efficacy of M-mode echocardiography for evaluating changes in cardiac structure and function following myocardial infarction in rats.

January 1, 2014Research in Cardiovascular MedicineOpen Access

Echocardiographic evaluation of cardiac function in ischemic rats: Value of m-mode echocardiography

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Why the study?

Does M-mode echocardiography accurately evaluate cardiac structure and function in normal and MI-induced adult rats?

Population

48 male Wistar rats weighing 280-300 grams, normal and MI-induced via left anterior descending coronary…

Comparison

M-mode echocardiography vs Baseline (pre-operation) measurements

Design

Preclinical

Authors

ASAnita SadeghpourMedStar Washington Hospital Center AAAmirDarbandi AzarIran University of Medical Sciences FTFatemeh TavakoliKerman University of Medical Sciences

Discussion

Member takes

Implication

Supports M-mode echocardiography for validating LAD ligation in rat MI models; leaves open translation to human cardiac assessment.

Key Points

To determine the feasibility and efficacy of M-mode echocardiography for evaluating changes in cardiac structure and function following myocardial infarction in rats.
Studied 48 male Wistar rats weighing 280–300 g undergoing left anterior descending coronary artery (LAD) ligation to induce myocardial infarction.
Performed baseline and post-operative M-mode echocardiographic evaluations and analyzed structural and hemodynamic parameters using SPSS 20.0.
Induced myocardial infarction resulted in statistically significant reductions in fractional shortening and ejection fraction (P < 0.01).
End-systolic diameter and systolic volume increased significantly after LAD ligation (P < 0.05).

Structured PICO

Does M-mode echocardiography accurately evaluate cardiac structure and function in normal and MI-induced adult rats?

Population

48 male Wistar rats weighing 280-300 grams, normal and MI-induced via left anterior descending coronary artery (LAD) ligation.

Intervention

M-mode echocardiography

Comparator

Baseline (pre-operation) measurements

Outcome

Echocardiographic alterations (Fractional shortening, Ejection Fraction, end systolic diameter, and systolic volume)surrogate

M-mode echocardiography is a feasible and precise method to assess the success of LAD ligation-induced myocardial infarction in rats.

Cite This Study

Sadeghpour et al. (2014) studied this question.

synapsesocial.com/papers/6a7431dfc0dd22c6076e8872 https://doi.org/10.5812/cardiovascmed.22941

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Echocardiographic evaluation of cardiac function in ischemic rats: Value of m-mode echocardiography

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Echocardiographic evaluation of cardiac function in ischemic rats: Value of m-mode echocardiography

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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