Why the study?
Does ascending aorta constriction increase left ventricular mass and myocardial performance index compared to sham operation in male Wistar rats?
Does ascending aorta constriction increase left ventricular mass and myocardial performance index compared to sham operation in male Wistar rats?
The myocardial performance index (MPI) is a useful echocardiographic marker for detecting early alterations in ventricular performance in a rat model of left ventricular hypertrophy.
MPI tracks early LV changes in rat pressure overload; leaves open clinical translation.
Myocardial hypertrophy is the hallmark of chronic pressure overload and the myocardial performance index (MPI) is an easily recordable measurement of Doppler time intervals. In this study, the utility of using MPI to assess the progression of hypertrophy in the aortic-banded rat model was evaluated. Male Wistar rats (70-90 g) underwent ascending aorta constriction (n = 4) or a sham operation (n = 5). High-resolution echocardiography was performed 4, 7, 10, and 12 weeks after the surgery. Over this follow-up interval, animals in the aortic-banded group demonstrated an increase in their mean left ventricular (LV) mass and MPI compared with controls. MPI reflects ventricular performance in small animals with LV hypertrophy, showing alterations early after aorta constriction.
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Salemi et al. (2004) studied this question.
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