Population
C57BL/6 mice
Comparison
Transverse aortic constriction (TAC) vs Sham operation
Design
Preclinical
Follow-up
11 weeks
Authors
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Supports noninvasive monitoring of hypertrophy and dysfunction in mouse models; confirms echo validity for pressure-overload research but leaves human translation open.
Echocardiography is a sensitive and valid method for assessing myocardial hypertrophy and systolic dysfunction induced by pressure overload in mouse models.
Liao et al. (2002) studied this question.
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