Key result
Transverse aortic constriction in mice caused an immediate decline in LV systolic performance and increased peak systolic wall stress, which recovered to baseline levels with compensatory LV hypertrophy over 10-20 days.
Authors
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Preclinical only; leaves open translation of compensatory hypertrophy to human pressure-overload states.
Nakamura et al. (2001) studied Left ventricular hypertrophy and pressure overload. Transverse aortic constriction (TAC) vs. Sham operation was evaluated on LV contractile performance, peak systolic wall stress index (WSI), and LV mass index. Transverse aortic constriction in mice caused an immediate decline in LV systolic performance and increased peak systolic wall stress, which recovered to baseline levels with compensatory LV hypertrophy over 10-20 days.
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