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January 1, 2023The Journal of Cardiovascular AgingOpen Access

Characterization of atrial and ventricular remodeling in an improved minimally invasive mouse model of transverse aortic constriction

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Why the study?

Conventional transverse aortic constriction in animal models of heart failure is highly invasive and associated with severe inflammation and excessive perioperative mortality.

Population

Mice undergoing transverse aortic constriction

Comparison

Minimally invasive transverse aortic constriction vs sham controls

Design

Animal experimental study

Follow-up

8 weeks

Authors

JNJosé Alberto Navarro‐GarcíaSLSatadru K. LahiriYAYuriana Aguilar-Sánchez

Discussion

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Overview

Supports preclinical HF modeling in mice; leaves open clinical translation.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Navarro‐García et al. (2023) studied this question.

synapsesocial.com/papers/6a0a590bfdd00ab7863dcdf4https://doi.org/10.20517/jca.2023.18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice2012 · 27 citations
  2. 2O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice2022 · 8 citations
  3. 3Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload2003 · 244 citations
  4. 4In-depth characterization of a mouse model of postoperative atrial fibrillation2022 · 9 citations
  5. 5Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling2020 · 51 citations