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April 25, 2020Heart Failure ReviewsOpen Access

The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis

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Why the study?

The transverse aortic constriction model is frequently used to study adverse cardiac remodeling upon pressure overload, but the most important characteristics defining the degree of cardiac remodeling in this model needed to be defined.

Does transverse aortic constriction (TAC) induce consistent adverse cardiac remodeling in wild-type mouse/rat models?

Population

502 articles and > 3000 wild-type, untreated animals (mice/rats) undergoing TAC

Comparison

Animals undergoing transverse aortic constriction vs control group

Design

Systematic review and meta-analysis

Authors

LBLena BoschJHJudith J. de HaanMBMarissa Bastemeijer

Discussion

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Overview

TAC model heterogeneity questions translational reliability of preclinical HF data; challenges validity of prior animal studies without improved reporting standards.

Structured PICO

Does transverse aortic constriction (TAC) induce consistent adverse cardiac remodeling in wild-type mouse/rat models?

P
Population
502 articles pooling > 3000 wild-type, untreated animals (mice/rats) undergoing transverse aortic constriction (TAC), strongly biased towards male C57Bl/6 mice (66% of studies).
I
Intervention
Transverse aortic constriction (TAC) model (mostly using ketamine/xylazine anesthetics, 27G needle constriction, and silk sutures)
C
Comparator
Control group
O
Outcome
Degree of cardiac remodeling assessed by echocardiography or MRI outcome parameterssurrogate

The TAC heart failure animal model shows substantial heterogeneity in functional outcomes despite homogeneous experimental designs, highlighting significant methodological and reporting quality issues in preclinical studies.

Limitations

  • Strong bias towards the use of specific mouse lines (male C57Bl/6)
  • Poor reporting of characteristics of study quality (only 12% reported randomization, 23% blinding, 2% sample size calculation)
  • Substantial unexplained heterogeneity in functional outcome measures

Cite This Study

Bosch et al. (2020) studied this question.

synapsesocial.com/papers/69bc7d74106136e116a13bd4https://doi.org/10.1007/s10741-020-09960-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A time-series minimally invasive transverse aortic constriction mouse model for pressure overload-induced cardiac remodeling and heart failure2023 · 17 citations
  2. 2Characterization of atrial and ventricular remodeling in an improved minimally invasive mouse model of transverse aortic constriction2023 · 2 citations
  3. 3Transverse Aortic Constriction in Mice2010 · 140 citations
  4. 4The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice2016 · 44 citations
  5. 5Distinct Phenotypes Induced by Different Degrees of Transverse Aortic Constriction in C57BL/6N Mice2021 · 22 citations