Why the study?
Little is known about cardiac remodeling in C57BL/6NTac mice as cardiac function progresses from compensation to decompensation following transverse aortic constriction.
Population
BL/6J and BL/6N mice
Comparison
BL/6N mice vs BL/6J mice subjected to pressure overload via TAC
Design
Preclinical animal study
Key result
Following transverse aortic constriction, C57BL/6NTac mice developed eccentric hypertrophy with deteriorating cardiac function and fibrosis, whereas C57BL/6J mice were more resilient to cardiac stress.
Authors
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C57BL/6NTac and C57BL/6J mouse substrains exhibit markedly different cardiac remodeling responses to transverse aortic constriction, necessitating careful substrain selection in heart failure models.
C57BL/6NTac and C57BL/6J mouse substrains exhibit markedly different cardiac remodeling responses to transverse aortic constriction, necessitating careful substrain selection in heart failure models.
Zi et al. (2019) studied Cardiac hypertrophy and heart failure. Transverse aortic constriction (TAC) in C57BL/6NTac mice vs. Transverse aortic constriction (TAC) in C57BL/6J mice was evaluated on Cardiac remodeling and function. Following transverse aortic constriction, C57BL/6NTac mice developed eccentric hypertrophy with deteriorating cardiac function and fibrosis, whereas C57BL/6J mice were more resilient to cardiac stress.