November 29, 2022Frontiers in PhysiologyOpen Access

ICR mice developed reduced systolic function and severe lung congestion 4 weeks post-TAC, whereas C57BL/6J did not, demonstrating severer fibrotic remodeling and poor behavioral performance in ICR mice.

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Why the study?

Phenotypic variation occurs among mouse strains after transverse aortic constriction, and less is known about this pressure overload model in ICR mice.

Population

ICR and C57BL/6J mice

Comparison

TAC vs sham operation across ICR and C57BL/6J mouse strains

Follow-up

4 weeks

Authors

MHMengying Huang LYLishuang Yu XWXiaoping Wang

Discussion

Member takes

Overview

ICR mice show TAC sensitivity suitable for HF modeling; extends strain comparisons but leaves open translational validation.

Structured PICO

Population

ICR and C57BL/6J mice

Intervention

Transverse aortic constriction (TAC)

Comparator

Sham-operated mice and comparison between the two strains

Outcome

Phenotypic variation including echocardiography, organ index, morphology, and histology at 1, 2, and 4 weeks post-TACsurrogate

The ICR mouse strain is highly sensitive to TAC-induced heart failure, presenting a robust model for studying pressure overload-induced HF mechanisms and drug interventions.

Cite This Study

Huang et al. (2022) studied this question.

synapsesocial.com/papers/6a7129b184cc45bb7bdfe430 https://doi.org/10.3389/fphys.2022.1026884

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November 29, 2022Frontiers in PhysiologyOpen Access

ICR mice developed reduced systolic function and severe lung congestion 4 weeks post-TAC, whereas C57BL/6J did not, demonstrating severer fibrotic remodeling and poor behavioral performance in ICR mice.

View Full Paper

Ask AI

Bookmark

Why the study?

Phenotypic variation occurs among mouse strains after transverse aortic constriction, and less is known about this pressure overload model in ICR mice.

Population

ICR and C57BL/6J mice

Comparison

TAC vs sham operation across ICR and C57BL/6J mouse strains

Follow-up

4 weeks

Authors

MHMengying Huang LYLishuang Yu XWXiaoping Wang

Discussion

Member takes

Overview

ICR mice show TAC sensitivity suitable for HF modeling; extends strain comparisons but leaves open translational validation.

Structured PICO

Population

ICR and C57BL/6J mice

Intervention

Transverse aortic constriction (TAC)

Comparator

Sham-operated mice and comparison between the two strains

Outcome

Phenotypic variation including echocardiography, organ index, morphology, and histology at 1, 2, and 4 weeks post-TACsurrogate

The ICR mouse strain is highly sensitive to TAC-induced heart failure, presenting a robust model for studying pressure overload-induced HF mechanisms and drug interventions.

Cite This Study

Huang et al. (2022) studied this question.

synapsesocial.com/papers/6a7129b184cc45bb7bdfe430 https://doi.org/10.3389/fphys.2022.1026884

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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