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May 25, 2013AJP Heart and Circulatory PhysiologyOpen Access

Substrain specific response to cardiac pressure overload in C57BL/6 mice

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Authors

LGLorena Garcia‐MenendezGKGeorgios KaramanlidisSKStephen C. Kolwicz

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Overview

Randomized trial examines cardiac response differences across C57BL/6 substrains, indicating variability in study interpretations.

Key Points

  • This research seeks to identify substrain-specific differences in cardiac response to pressure overload in C57BL/6 mice.
  • Evaluated survival and cardiac function after transverse aortic constriction (TAC) in three substrains: C57BL/6J, C57BL/6NCrl, and C57BL/6NTac.
  • Assessed expression of hypertrophic markers like Bnp and analyzed heart and lung weights.
  • Histological evaluation of left ventricular morphology was performed.
  • Survival and cardiac function were significantly lower in the C57BL/6NCrl and C57BL/6NTac substrains compared to C57BL/6J after TAC.
  • C57BL/6NCrl mice showed greater heart weight and lung weight compared to C57BL/6J.
  • Histology revealed left ventricular dilatation in C57BL/6NCrl and C57BL/6NTac, while C57BL/6J exhibited increased wall thickness without dilatation.

Cite This Study

Garcia‐Menendez et al. (2013) studied this question.

synapsesocial.com/papers/6a092f2e89dc12f767d26024https://doi.org/10.1152/ajpheart.00088.2013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac hypertrophy or failure? - A systematic evaluation of the transverse aortic constriction model in C57BL/6NTac and C57BL/6J substrains2019 · 40 citations
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  3. 3Distinct Phenotypes Induced by Different Degrees of Transverse Aortic Constriction in C57BL/6N Mice2021 · 22 citations
  4. 4Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice2020 · 17 citations
  5. 5Comparative phenotyping of C57BL/6J substrains reveals distinctive patterns of cardiac aging2025 · 4 citations