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January 30, 2025GeroScienceOpen Access

Cardiac aging manifests as moderate systolic dysfunction with decreased ejection fraction and cardiac hypertrophy in B6JRj mice, whereas B6JCrl mice display no functional changes with age.

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Why the study?

C57BL/6J mice from different suppliers result in diverse substrains exhibiting notable phenotypic differences, requiring assessment to ensure a suitable phenotype of cardiac aging.

Population

Young (5 months) and old (24 months) B6J mice from two substrains (B6JRj and B6JCrl)

Comparison

B6JRj mice vs B6JCrl mice at 5 and 24 months of age

Authors

SWSophia WalterNHNiklas HegemannSHSteffen P. Häseli

Discussion

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Overview

Myocardial fibrosis increases consistently with age across B6J substrains; leaves open standardization of supplier effects in cardiac aging models.

Structured PICO

P
Population
Young (5 months) and old (24 months) C57BL/6J mice from two substrains: B6JRj (Janvier) and B6JCrl (Charles River)
I
Intervention
B6JRj (Janvier) substrain
C
Comparator
B6JCrl (Charles River) substrain
O
Outcome
Cardiac aging phenotype including myocardial fibrosis, cardiac hypertrophy, ejection fraction, and cardiomyocyte functionsurrogate

The choice of C57BL/6J mouse substrain significantly impacts the observed cardiac aging phenotype, with B6JRj mice developing systolic dysfunction unlike B6JCrl mice.

Cite This Study

Walter et al. (2025) studied this question.

synapsesocial.com/papers/6a8d04055811516ab8099bf1https://doi.org/10.1007/s11357-025-01543-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Phenotypic Assessment of Cardiac Pathology, Physiology, and Gene Expression in C3H/HeJ, C57BL/6J, and B6C3F1/J Mice2010 · 11 citations
  2. 2Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice2024 · 1 citations
  3. 3Substrain specific response to cardiac pressure overload in C57BL/6 mice2013 · 107 citations
  4. 4Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains2010 · 88 citations
  5. 5A matter of food and substrain: obesogenic diets induce differential severity of cardiac remodeling and diastolic dysfunction in C57Bl/6J and C57Bl/6N substrains2024