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April 22, 2021Frontiers in Cardiovascular MedicineOpen Access

Mice subjected to 27G TAC had severe cardiac dysfunction and fibrosis at 4 weeks, whereas 26G TAC showed milder responses and 25G TAC showed no obvious cardiac dysfunction or heart failure characteristics.

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Why the study?

Few studies have directly compared phenotypes induced by different degrees of aortic constriction in transverse aortic constriction models, and none had evaluated these differences in C57BL/6N mice.

Population

C57BL/6N mice aged 10 weeks

Comparison

Sham vs 25G TAC vs 26G TAC vs 27G TAC surgery

Follow-up

4 weeks

Authors

HDHaiyan DengLMLeilei MaFKFei‐Juan Kong

Discussion

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Overview

Graded TAC in mice extends options for HF model selection in preclinical research; leaves clinical translation open pending further validation.

Structured PICO

P
Population
C57BL/6N mice aged 10 weeks
I
Intervention
Transverse aortic constriction (TAC) surgery using 25G, 26G, or 27G needles
C
Comparator
Sham surgery
O
Outcome
Cardiac phenotypes including pressure gradient, cardiac hypertrophy, cardiac function, heart failure situation, survival condition, and cardiac fibrosissurrogate

Different degrees of transverse aortic constriction (25G, 26G, 27G) induce distinct, graded phenotypes of cardiac hypertrophy and heart failure in C57BL/6N mice, which is critical for selecting the appropriate model severity in preclinical studies.

Cite This Study

Deng et al. (2021) studied this question.

synapsesocial.com/papers/6a894f44a14d41d02f431dechttps://doi.org/10.3389/fcvm.2021.641272
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A time-series minimally invasive transverse aortic constriction mouse model for pressure overload-induced cardiac remodeling and heart failure2023 · 17 citations
  2. 2Cardiac hypertrophy or failure? - A systematic evaluation of the transverse aortic constriction model in C57BL/6NTac and C57BL/6J substrains2019 · 40 citations
  3. 3Evaluation of the transverse aortic constriction model in ICR and C57BL/6J mice2022 · 7 citations
  4. 4Transverse Aortic Constriction in Mice2010 · 262 citations
  5. 5Transverse Aortic Constriction in Mice2010 · 140 citations