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March 24, 2012Experimental PhysiologyOpen Access

Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice

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Why the study?

Does minimally invasive transverse aortic banding (MTAB) effectively induce cardiac hypertrophy and dysfunction in mice compared to sham surgery?

Population

Mice

Comparison

Minimally invasive transverse aortic banding… vs Sham surgery

Design

Preclinical

Follow-up

Up to 4 weeks

Authors

TMTamara P. MartinUniversity of GlasgowEREmma RobinsonUniversity of New BrunswickAHAdam HarveyNewcastle University

Discussion

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Member takes

Implication

Supports MTAB as a mouse model for pressure-overload remodeling; leaves open translation to human HF therapies.

Structured PICO

Does minimally invasive transverse aortic banding (MTAB) effectively induce cardiac hypertrophy and dysfunction in mice compared to sham surgery?

P
Population
Mice
I
Intervention
Minimally invasive transverse aortic banding (MTAB) under isoflurane anaesthesia
C
Comparator
Sham surgery
O
Outcome
Development and progression of cardiac hypertrophy and dysfunction (assessed by blood pressure, heart weight to body weight ratio, fractional shortening, and left ventricular end-diastolic pressure)surrogate

Minimally invasive transverse aortic banding (MTAB) is a viable and effective experimental model for inducing and studying the progression of cardiac hypertrophy and heart failure in mice.

Cite This Study

Martin et al. (2012) studied this question.

synapsesocial.com/papers/69d576e462196bac97d9bd1dhttps://doi.org/10.1113/expphysiol.2012.065573

Topics

Heart failureHFrEF treatment
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