What does this research mean for the field?

The regression of pressure overload-induced left ventricular hypertrophy involves distinct time courses for morphological, functional, and genetic components, with longer periods of initial pressure overload resulting in slower and less complete regression. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 21, 2005AJP Heart and Circulatory Physiology

Regression of pressure overload-induced left ventricular hypertrophy in mice

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Population

Mice subjected to aortic banding for 4 or 8 wk to establish left ventricular hypertrophy (LVH)

Design

Preclinical

Follow-up

6 wk

Authors

XGXiao‐Ming GaoXinjiang Medical University HKHelen KiriazisHeart Failure & Transplant XMXiao‐Lei MooreDiscovery Institute

Discussion

Member takes

Implication

May limit complete LV recovery after prolonged overload in mice; leaves open translation to human pressure-overload states.

Structured PICO

Population

Mice subjected to aortic banding for 4 or 8 wk to establish left ventricular hypertrophy (LVH)

Intervention

Release of aortic banding (debanding) for 6 wk

Outcome

Time course for the development and subsequent regression of LVH as well as accompanying alterations in cardiac function, histology, and gene expressionsurrogate

The extent and rate of left ventricular hypertrophy regression following relief of pressure overload in mice depends on the duration of the preceding pressure overload.

Cite This Study

Gao et al. (2005) studied this question.

synapsesocial.com/papers/6a1de403813f0becab34f52d https://doi.org/10.1152/ajpheart.00836.2004

Topics

Echocardiography

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January 21, 2005AJP Heart and Circulatory Physiology

Regression of pressure overload-induced left ventricular hypertrophy in mice

View Full Paper

Ask AI

Bookmark

Population

Mice subjected to aortic banding for 4 or 8 wk to establish left ventricular hypertrophy (LVH)

Design

Preclinical

Follow-up

6 wk

Authors

XGXiao‐Ming GaoXinjiang Medical University HKHelen KiriazisHeart Failure & Transplant XMXiao‐Lei MooreDiscovery Institute

Discussion

Member takes

Implication

May limit complete LV recovery after prolonged overload in mice; leaves open translation to human pressure-overload states.

Structured PICO

Population

Mice subjected to aortic banding for 4 or 8 wk to establish left ventricular hypertrophy (LVH)

Intervention

Release of aortic banding (debanding) for 6 wk

Outcome

Time course for the development and subsequent regression of LVH as well as accompanying alterations in cardiac function, histology, and gene expressionsurrogate

The extent and rate of left ventricular hypertrophy regression following relief of pressure overload in mice depends on the duration of the preceding pressure overload.

Cite This Study

Gao et al. (2005) studied this question.

synapsesocial.com/papers/6a1de403813f0becab34f52d https://doi.org/10.1152/ajpheart.00836.2004

Also Consider

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Topics

Echocardiography

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