June 1, 1992Cardiovascular Research
Left ventricular hypertrophy in a canine model of reversible pressure overload
Key result
Removal of pressure overload in a canine model significantly reduced the left ventricular weight to body weight ratio from 7.2 to 5.3 g/kg (p<0.05) over six months.
Why the study?
Does removal of pressure overload reduce left ventricular hypertrophy in a canine model?
Population
6 puppies undergoing ascending aortic banding at 9 weeks of age to induce left ventricular pressure overload…
Design
Preclinical
Follow-up
10 months total (6 months after balloon aortoplasty)
Authors
Discussion
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Implication
Supports LVH regression after pressure relief in canines; leaves open translation to human aortic stenosis.
Structured PICO
Does removal of pressure overload reduce left ventricular hypertrophy in a canine model?
P
Population
6 puppies undergoing ascending aortic banding at 9 weeks of age to induce left ventricular hypertrophy, followed longitudinally for 10 months.
I
Intervention
Surgical removal of the aortic band followed one month later by balloon aortoplasty to remove residual gradient
O
Outcome
Extent and time course of the progression and regression of pressure overload left ventricular hypertrophy (measured by left ventricular weight to body weight ratio and echocardiographic left ventricular mass)surrogate
Main Result
Absolute Event Rate: 5.3% vs 7.2%
p-value: p=<0.05
In a canine model, removal of pressure overload via surgical debanding and balloon aortoplasty leads to significant regression of left ventricular hypertrophy.
Cite This Study
Ishihara et al. (1992) studied Left ventricular hypertrophy (n=6). Removal of pressure overload (surgical band removal and balloon aortoplasty) vs. Baseline (hypertrophied state before removal) was evaluated on Left ventricular weight to body weight ratio (g/kg) (p=<0.05). Removal of pressure overload in a canine model significantly reduced the left ventricular weight to body weight ratio from 7.2 to 5.3 g/kg (p<0.05) over six months.