Key result
Chronic right ventricular pressure overload via pulmonary artery banding in dogs resulted in a significant loss of left ventricular chamber and intrinsic myocardial compliance at 8 months.
Why the study?
Does chronic pressure overload and right ventricular hypertrophy alter the diastolic properties of the left ventricle in adult dogs?
Population
20 adult dogs (6 banded, 14 control)
Comparison
Banding of the pulmonary artery to induce… vs Unbanded control dogs
Design
Preclinical
Follow-up
8 months
Authors
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May indicate LV diastolic impairment in RV overload; leaves open human translation and therapeutic targeting.
Does chronic pressure overload and right ventricular hypertrophy alter the diastolic properties of the left ventricle in adult dogs?
Chronic right ventricular pressure overload and hypertrophy lead to alterations in left ventricular mass, geometry, and material properties, compromising LV chamber compliance.
Visner et al. (1986) studied Right ventricular hypertrophy and pressure overload (n=20). Pulmonary arterial banding vs. Control (no banding) was evaluated on Left ventricular diastolic properties and dynamic geometry (chamber and myocardial compliance). Chronic right ventricular pressure overload via pulmonary artery banding in dogs resulted in a significant loss of left ventricular chamber and intrinsic myocardial compliance at 8 months.
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