Key result
Abdominal aorta banding in rats increases LV wall thickness ~35% vs sham, correlating with heart mass.
Why the study?
Echocardiography is a sensitive noninvasive method to study myocardial remodeling, but in vivo time-course assessment of LV structural and functional changes after aortic banding requires validation by necropsy.
Does abdominal aorta banding induce progressive left ventricular hypertrophy in Wistar rats that can be reliably assessed by echocardiography?
Population
Wistar rats subjected to abdominal aorta banding or sham operation with age- and sex-matched controls
Comparison
Abdominal aorta banding vs sham operation and unoperated controls
Design
Preclinical in vivo study with necropsy validation
Follow-up
45 days
Authors
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Validates serial echocardiography for tracking LV remodeling in rat aortic banding; leaves open translation to human LVH.
Does abdominal aorta banding induce progressive left ventricular hypertrophy in Wistar rats that can be reliably assessed by echocardiography?
Effect estimate: r=0.724
p-value: p=< 0.001
Abdominal aorta banding provides a reliable, time-dependent model of left ventricular hypertrophy in rats that correlates well with necropsy findings and avoids the need for thoracotomy.
Stoyanova et al. (2006) studied Left ventricular hypertrophy. Abdominal aorta banding vs. Sham operation was evaluated on Correlation between echocardiographic left ventricular wall thickness and actual whole heart mass (r=0.724, p=< 0.001). Abdominal aorta banding in rats increased left ventricular wall thickness to 35% compared with sham at 45 days, correlating well with actual whole heart mass (r=0.724, P<0.001).
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