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May 1, 1993Journal of Applied Physiology

Echocardiographic evaluation of size, function, and mass of normal and hypertrophied rat ventricles

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Why the study?

Does two-dimensional echocardiography reliably evaluate cardiac structure and function in normal and hypertrophied rat ventricles?

Population

Rats with surgically induced renovascular hypertension (hypertrophied, HYP) and normal (SH) rats

Comparison

Two-dimensional echocardiography and Doppler… vs Normal (SH) rats evaluated with the same method

Design

Preclinical

Authors

DPD. G. PawlushPennsylvania State UniversityRMR. L. MooreUniversity of Colorado BoulderTMTimothy I. MuschHeart Failure & Transplant

Discussion

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Implication

Supports echo for serial LVH assessment in rat models; leaves open human translation.

Key Points

  • This study aimed to evaluate cardiac structure and function in normal and hypertrophied rat ventricles using echocardiography.
  • Utilized echocardiographic system with Doppler capabilities for imaging and analysis.
  • Induced renovascular hypertension in rats to create hypertrophied hearts for comparison.
  • Measured left ventricular dimensions, volumes, and wall thicknesses at 7.5-mHz frequency.
  • HYP hearts showed a 62% increase in left ventricular posterior wall thickness (P<0.05).
  • HYP hearts had a 44% increase in calculated ventricular mass (P<0.05).
  • Systolic function remained normal in HYP hearts with no significant differences in Doppler flow velocities.

Structured PICO

Does two-dimensional echocardiography reliably evaluate cardiac structure and function in normal and hypertrophied rat ventricles?

P
Population
Rats with surgically induced renovascular hypertension (hypertrophied, HYP) and normal (SH) rats
I
Intervention
Two-dimensional echocardiography and Doppler evaluation using a 7.5-mHz single-crystal mechanical transducer
C
Comparator
Normal (SH) rats evaluated with the same method
O
Outcome
Echocardiographic measurement of left ventricular posterior wall thickness and calculated ventricular masssurrogate

Two-dimensional echocardiography provides a reliable, noninvasive method to evaluate cardiac structure and function, including left ventricular hypertrophy, in rat models.

Cite This Study

Pawlush et al. (1993) studied this question.

synapsesocial.com/papers/6a206d2fddea50bfc43d2064https://doi.org/10.1152/jappl.1993.74.5.2598

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic Assessment of Left Ventricular Hypertrophy in Rats Using a Simplified Approach1994 · 14 citations
  2. 2DEVELOPMENT AND VALIDATION OF ECHOCARDIOGRAPHY METHODS FOR ESTIMATING LEFT VENTRICULAR MASS IN RATS1992 · 23 citations
  3. 3In Vivo Assessment of Left Ventricular Hypertrophy in Rats: Necropsy Validation2006
  4. 4Visualization of the Heart and Determination of Left Ventricular Mass in Rats by Echocardiography.1991 · 9 citations
  5. 5Rat model of exercise-induced cardiac hypertrophy: hemodynamic characterization using left ventricular pressure-volume analysis2013 · 82 citations