June 1, 1994American Journal of Hypertension
Echocardiographic Assessment of Left Ventricular Hypertrophy in Rats Using a Simplified Approach
Key result
A simplified echocardiographic ellipsoidal model accurately estimated LV mass in rats, demonstrating 78% sensitivity and 100% specificity for anatomic left ventricular hypertrophy.
Why the study?
Does a simplified echocardiographic approach using an estimated long axis accurately determine left ventricular mass in rats compared to necropsy?
Population
58 male Wistar rats (41 normotensive and 17 hypertensive)
Comparison
Simplified echocardiographic assessment of LV… vs Necropsy LV weight and the cube-function formula
Design
Preclinical
Authors
Discussion
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Implication
Supports simplified echo for LV mass in rat hypertension models; leaves open validation beyond this species.
Study Design
Type
Observational (n=58)
Structured PICO
Does a simplified echocardiographic approach using an estimated long axis accurately determine left ventricular mass in rats compared to necropsy?
P
Population
58 normotensive and hypertensive male Wistar rats evaluated for echocardiographic assessment of left ventricular hypertrophy.
E
Exposure
Simplified echocardiographic assessment of LV mass using an ellipsoidal model with a constant (12.28 mm) to estimate LV long axis
C
Comparator
Necropsy LV weight and the cube-function formula
O
Outcome
Correlation between echocardiographic LV mass and necropsy LV weightsurrogate
Main Result
Effect estimate: Correlation 0.89
A simplified echocardiographic method using an estimated long axis provides accurate assessment of left ventricular mass in rat models, offering a useful tool for hypertension research.
Limitations
- Long axis (L) was not measurable by two-dimensional echocardiography due to high heart rate
Cite This Study
Simone et al. (1994) conducted an observational in Left ventricular hypertrophy (n=58). Simplified echocardiographic ellipsoidal model vs. Necropsy LV weight was evaluated on Correlation between necropsy LV weight and echocardiographic LV mass (Correlation 0.89). A simplified echocardiographic ellipsoidal model accurately estimated LV mass in rats, demonstrating 78% sensitivity and 100% specificity for anatomic left ventricular hypertrophy.