What is the clinical evidence from this study?

Population: Left ventricular mass measurement (n=91). Intervention: Two-dimensional area-length method vs. Standard M-mode method. Primary outcome: Correlation and accuracy of LVM estimates compared with necropsy weights (r = 0.92 vs 0.81).

What question did this study set out to answer?

To assess and compare the accuracy and reproducibility of two-dimensional area-length echocardiography against standard M-mode imaging for estimating left ventricular mass in mice.

May 1, 2001AJP Heart and Circulatory Physiology

Accuracy of echocardiographic estimates of left ventricular mass in mice

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Key result

The two-dimensional area-length method showed higher correlation (r=0.92 vs 0.81) and accuracy (bias 1.4% vs 36.7%) than the M-mode method for estimating left ventricular mass in mice.

Why the study?

Does the two-dimensional area-length method improve the accuracy of left ventricular mass estimation compared to the M-mode method in mice?

Key Points

To assess and compare the accuracy and reproducibility of two-dimensional area-length echocardiography against standard M-mode imaging for estimating left ventricular mass in mice.
Transthoracic echocardiography was performed with a 15 MHz linear transducer (120 Hz) on 91 CD-1 mice, including 38 normal controls, 44 aortic-banded mice, and 9 with inherited dilated cardiomyopathy.
In vivo left ventricular mass estimates calculated via M-mode, two-dimensional area-length, and truncated ellipsoid geometric models were compared directly against post-mortem necropsy weights (range 62–210 mg).
The area-length method demonstrated a higher correlation with necropsy weight than M-mode (r = 0.92 vs. r = 0.81) and markedly improved accuracy (bias ± SD: 1.4 ± 27.1% vs. 36.7 ± 51.6%).
Calculations between end-systolic and end-diastolic measurements did not differ significantly, and the truncated ellipsoid model achieved accuracy similar to the area-length method.

Structured PICO

Does the two-dimensional area-length method improve the accuracy of left ventricular mass estimation compared to the M-mode method in mice?

Population

91 CD-1 mice (38 normal, 44 aortic banded, and 9 inherited dilated cardiomyopathy) with LV sizes and weights ranging from 62-210 mg

Intervention

Two-dimensional echocardiography using the area-length method (and truncated ellipsoid estimation) to estimate left ventricular mass

Comparator

Standard M-mode echocardiography method

Outcome

Accuracy and correlation of left ventricular mass estimates compared with necropsy weightssurrogate

Main Result

Effect estimate: r = 0.92 vs 0.81

The two-dimensional area-length echocardiographic method provides a more accurate and reproducible noninvasive estimate of left ventricular mass in mice compared to the standard M-mode method.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Favors 2D area-length over M-mode for murine LV mass estimation; leaves open translation to human studies.

Cite This Study

Collins et al. (2001) studied Left ventricular mass measurement (n=91). Two-dimensional area-length method vs. Standard M-mode method was evaluated on Correlation and accuracy of LVM estimates compared with necropsy weights (r = 0.92 vs 0.81). The two-dimensional area-length method showed higher correlation (r=0.92 vs 0.81) and accuracy (bias 1.4% vs 36.7%) than the M-mode method for estimating left ventricular mass in mice.

synapsesocial.com/papers/6a0dda6be51d8d6d0c09dc3d https://doi.org/10.1152/ajpheart.2001.280.5.h1954

Topics

Echocardiography

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Accuracy of echocardiographic estimates of left ventricular mass in mice

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Accuracy of echocardiographic estimates of left ventricular mass in mice

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider