What question did this study set out to answer?

To evaluate the accuracy of three standard echocardiographic algorithms for measuring left ventricular mass across neonatal, adolescent, and adult developmental stages in mice.

October 26, 2006Echocardiography

Echocardiographic Assessment of Left Ventricular Mass in Neonatal and Adult Mice: Accuracy of Different Echocardiographic Methods

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Left ventricular mass assessment (n=35). Intervention: Echocardiographic algorithms (Penn, Area Length, Truncated Ellipsoid) vs. Histomorphometry. Primary outcome: Accuracy of left ventricular mass estimation compared to histomorphometry (r: 0.88).

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Key result

Two-dimensional echocardiographic assessment using the Area Length algorithm closely correlated with histomorphometry for left ventricular mass in mice (r=0.88).

Why the study?

Does high-resolution echocardiography accurately estimate left ventricular mass compared to histomorphometry in neonatal and adult mice?

Population

35 C57/BL6-mice in three early developmental stages

Comparison

High-resolution echocardiography using Penn… vs Histomorphometry

Design

Preclinical

Authors

AGAlexander GhanemInterventional Cardiology WRWilli Röll THToktam HashemiIslamic Azad University, Mashhad

Discussion

Member takes

Implication

Supports LV mass estimation via echocardiography in mouse models; leaves open human translation.

Key Points

To evaluate the accuracy of three standard echocardiographic algorithms for measuring left ventricular mass across neonatal, adolescent, and adult developmental stages in mice.
Conducted high-resolution echocardiography in 35 C57/BL6 mice using two-dimensional M-mode (Penn algorithm) and B-mode short- and long-axis views (Area Length and Truncated Ellipsoid algorithms).
Categorized mice into three heart-weight groups: small (<50 mg, n=12), adolescent (50–75 mg, n=13), and adult (75–100 mg, n=10), validating imaging calculations against histomorphometry.
Two-dimensional Area Length (r = 0.88, y = 1.21x - 12.1) and Truncated Ellipsoid (r = 0.86, y = 1.38x - 2.88) methods correlated more strongly with histomorphometry than the M-mode Penn algorithm (r = 0.71, y = 0.6x - 0.12), which consistently underestimated mass across all subgroups.
Diastolic Area Length demonstrated the lowest overall bias by underestimating mass by 3.2%.
Hearts under 50 mg correlated best with systolic Area Length, whereas adolescent and adult hearts exceeding 50 mg were most accurately quantified using diastolic Area Length and Truncated Ellipsoid methods.

Study Design

Type

Observational (n=35)

Structured PICO

Does high-resolution echocardiography accurately estimate left ventricular mass compared to histomorphometry in neonatal and adult mice?

Population

35 C57/BL6-mice in three early developmental stages (small hearts <50 mg n=12, adolescent 50-75 mg n=13, adult 75-100 mg n=10)

Intervention

High-resolution echocardiography using Penn (P), Area Length (AL), and Truncated Ellipsoid (TE) algorithms

Comparator

Histomorphometry

Outcome

Accuracy of left-ventricular mass (LVM) estimationsurrogate

Main Result

Effect estimate: r: 0.88

Two-dimensional echocardiography using the Area Length algorithm provides accurate estimation of left ventricular mass in mice across different developmental stages when compared to histomorphometry.

Cite This Study

Ghanem et al. (2006) conducted an observational in Left ventricular mass assessment (n=35). Echocardiographic algorithms (Penn, Area Length, Truncated Ellipsoid) vs. Histomorphometry was evaluated on Accuracy of left ventricular mass estimation compared to histomorphometry (r: 0.88). Two-dimensional echocardiographic assessment using the Area Length algorithm closely correlated with histomorphometry for left ventricular mass in mice (r=0.88).

synapsesocial.com/papers/6a11df03c031bb6829a5798b https://doi.org/10.1111/j.1540-8175.2006.00323.x

Topics

Echocardiography

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Echocardiographic Assessment of Left Ventricular Mass in Neonatal and Adult Mice: Accuracy of Different Echocardiographic Methods

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Echocardiographic Assessment of Left Ventricular Mass in Neonatal and Adult Mice: Accuracy of Different Echocardiographic Methods

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider