Key result
Novel 2D echo accurately measures LV mass in a porcine model within 1 g of necropsy.
Why the study?
Clinical evaluation requires reliable echocardiographic LVM quantification, prompting the validation of a novel 2D method against necropsy LVM compared to conventional methods.
Does a novel 2D echocardiographic method improve the accuracy of left ventricular mass quantification compared to conventional methods in a porcine model?
Does a novel 2D echocardiographic method improve the accuracy of left ventricular mass quantification compared to conventional methods in a porcine model?
Effect estimate: r = 0.70
Absolute Event Rate: -1% vs 26%
p-value: p=<0.001
A novel 2D echocardiographic method for left ventricular mass quantification demonstrated superior accuracy compared to conventional methods when validated against necropsy in a porcine model.
May enhance preclinical LVM assessment; leaves open human validation before clinical use.
Introduction Increased left ventricular mass (LVM) is one of the most powerful predictors of adverse cardiovascular events. Clinical evaluation requires reliable, accurate and reproducible echocardiographic LVM-quantification to manage patients. For this purpose, we have developed a novel two-dimensional (2D) method based on adding the mean wall thickness to the left ventricular volume acquired by the biplane method of disks, which has recently been validated in humans using cardiac magnetic resonance as reference value. We assessed the hypothesis that the novel method has better accuracy than conventional one-dimensional (1D) methods, when compared to necropsy LVM in pigs. Materials and Methods Echocardiography was performed during anesthesia in 34 Danish Landrace pigs, weight 47–59 kg. All pigs were euthanized, cardiac necropsy was performed and the left ventricle was trimmed and weighed for necropsy LVM. Trans-thoracic echocardiography was applied for parasternal images. Transdiaphragmal echocardiography was applied for the apical images, which are otherwise difficult to obtain in pigs. We compared the conventional 1D- and 2D-methods and the novel 2D-method to the LVM from cardiac necropsy. Results Necropsy LVM was 132 ± 11 g (mean ± SD). The novel method had better accuracy than other methods (mean difference ± 95% limits of agreement; coefficients of variation; standard error of the estimate, Pearson's correlation). Novel (−1 ± 20 g; 8%; 11 g; r = 0.70), Devereux (+26 ± 37 g; 15%; 33 g; r = 0.52), Area-Length (+27 ± 34 g; 13 %; 33 g; r = 0.63), Truncated Ellipsoid (+10 ± 30 g; 12%; 19 g; r = 0.63), biplane endo-/epicardial tracing (−3 ± 2 g; 10%; 14 g; r = 0.57). No proportional bias in linear regression was detected for any method, when compared to necropsy LVM. Conclusion We confirm high accuracy of the novel 2D-based method compared to conventional 1D/2D-methods.
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Kristensen et al. (2022) studied Left ventricular mass quantification (n=34). Novel 2D echocardiographic method vs. Conventional 1D/2D echocardiographic methods and necropsy was evaluated on Mean difference between echocardiographic left ventricular mass and necropsy left ventricular mass (r = 0.70, p=<0.001). A novel 2D-based echocardiographic method for left ventricular mass quantification demonstrated high accuracy compared to necropsy in a porcine model, with a mean difference of -1 g and a correlation of r=0.70.
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