What question did this study set out to answer?

This research aims to investigate how healed myocardial infarction affects the diastolic compliance of the left ventricle.

September 1, 1981Circulation ResearchOpen Access

Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.

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Why the study?

Does healed myocardial infarction alter left ventricular diastolic pressure-volume relations and systolic function in rats?

Key Points

This research aims to investigate how healed myocardial infarction affects the diastolic compliance of the left ventricle.
Studied 36 rats 26 days post left coronary artery ligation.
Measured peak cardiac output and left ventricular developed pressure during occlusion.
Continuously measured diastolic pressure and volume during saline infusion into potassium-arrested left ventricle.
Infarct size correlated with an increased left ventricular volume and improved diastolic compliance at pressures below 2.5 mm Hg.
Peak cardiac output and pressure-generating capacity decreased in proportion to infarct size.
Infarct-induced increases in diastolic volume offset reductions in flow-generating capacity due to systolic dysfunction.

Structured PICO

Does healed myocardial infarction alter left ventricular diastolic pressure-volume relations and systolic function in rats?

Population

36 rats 26 days after left coronary artery ligation

Intervention

Left coronary artery ligation (healed myocardial infarction model)

Comparator

Rats without infarctions

Outcome

Left ventricular diastolic pressure-volume relations and systolic function (peak cardiac output, stroke volume, peak left ventricular developed pressure)surrogate

Healed myocardial infarction in rats leads to increased left ventricular volume and compliance at low pressures, with systolic impairment proportional to infarct size.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports rat infarct models for remodeling studies; leaves open human translation and clinical relevance.

Cite This Study

Fletcher et al. (1981) studied this question.

synapsesocial.com/papers/69e143e7f608f0c4ffa1a12c https://doi.org/10.1161/01.res.49.3.618

View Full Paper

Ask AI

Bookmark

Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider