Population
6 mongrel dogs with experimental right ventricular wall infarction
Comparison
Volume loading followed by sequential opening of… vs Baseline and post-infarction state prior to…
Design
Preclinical
Authors
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Animal data on RVEDP-targeted volume loading in infarction should not change practice; leaves open pericardial interactions in human RV failure.
In an experimental model of right ventricular infarction, volume loading to a right ventricular diastolic pressure of 16 mm Hg restores cardiac output, while pericardial constraint limits ventricular filling through atrioventricular and direct ventricular interactions.
James E. Calvin (1991) studied this question.
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