Key result
Right ventricular ischemia induced by RCA occlusion reduced aortic flow by 24% (p<0.001) and shifted the interventricular septum leftward, with changes enhanced by an intact pericardium.
Why the study?
Does right ventricular ischemia alter left ventricular geometry and the end-diastolic pressure-volume relationship in open-chest dogs?
Population
16 open-chest dogs
Comparison
Right coronary artery occlusion for 2 min before… vs Preocclusion baseline and inferior vena caval…
Design
Preclinical
Authors
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RV ischemia effects on LV geometry and pericardial modulation are hypothesis-generating in dogs; human studies required before clinical relevance.
Does right ventricular ischemia alter left ventricular geometry and the end-diastolic pressure-volume relationship in open-chest dogs?
p-value: p=<0.001
Right ventricular ischemia causes a leftward shift of the interventricular septum and alters the LV end-diastolic pressure-volume relationship, effects that are enhanced by an intact pericardium.
Goto et al. (1985) studied Right ventricular ischemia (n=16). Right coronary artery (RCA) occlusion vs. Preocclusion baseline and post-pericardiectomy was evaluated on Aortic flow and septal-lateral dimension (p=<0.001). Right ventricular ischemia induced by RCA occlusion reduced aortic flow by 24% (p<0.001) and shifted the interventricular septum leftward, with changes enhanced by an intact pericardium.
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