Key result
Right coronary artery occlusion with an open pericardium produced a significantly smaller negative effect on cardiac output (P=0.03) and LV systolic pressure (P=0.02) than with an intact pericardium.
Why the study?
Does acute right ventricular dilatation in response to ischemia impair left ventricular systolic performance in a porcine model?
Population
12 40-kg pigs
Comparison
Right ventricular ischemia induced by balloon… vs Comparison between the 3 conditions
Design
Preclinical
Authors
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Hypothesis-generating in porcine RV infarction model; human studies needed before clinical relevance can be assessed.
Does acute right ventricular dilatation in response to ischemia impair left ventricular systolic performance in a porcine model?
p-value: p=0.03
Acute right ventricular dilatation within an intact pericardium impairs left ventricular systolic performance, highlighting the role of ventricular interdependence beyond mere changes in preload or compliance.
Brookes et al. (1999) studied Right ventricular ischemia and dilatation (n=12). Right coronary artery occlusion with open pericardium vs. Right coronary artery occlusion with intact pericardium was evaluated on Cardiac output and left ventricular systolic performance indices (p=0.03). Right coronary artery occlusion with an open pericardium produced a significantly smaller negative effect on cardiac output (P=0.03) and LV systolic pressure (P=0.02) than with an intact pericardium.
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