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September 1, 1987Journal of Applied Physiology

Influence of the pericardium on right and left ventricular filling in the dog

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Population

6 open-chest, pentobarbital sodium-anesthetized dogs

Comparison

Pericardiectomy vs Before pericardiectomy (baseline)

Design

Preclinical

Authors

DADeodato AssanelliBrescia UniversityWLWilbur Y.W. LewVeterans Medical Research Foundation of San DiegoRSRalph ShabetaiHeart Failure / Cardiomyopathy

Discussion

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Implication

Hypothesis-generating for differential pericardial constraint on RV versus LV filling; human studies needed before clinical relevance.

Structured PICO

P
Population
6 open-chest, pentobarbital sodium-anesthetized dogs
I
Intervention
Pericardiectomy
C
Comparator
Before pericardiectomy (baseline)
O
Outcome
Left and right ventricular (LV, RV) pressures and segment lengths (SL, LV free wall, and RV inflow and outflow tracts)surrogate

The pericardium exerts a proportionally greater constraint on right ventricular filling compared to left ventricular filling at higher end-diastolic pressures.

Cite This Study

Assanelli et al. (1987) studied this question.

synapsesocial.com/papers/6a86f369cbc6304817bef620https://doi.org/10.1152/jappl.1987.63.3.1025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pericardial influences on right and left ventricular filling dynamics.1991 · 38 citations
  2. 2The effect of pericardium on the end-systolic pressure-segment length relationship in canine left ventricle in acute volume overload.1983 · 19 citations
  3. 3The effect of pericardium on the diastolic properties of the heart -Experimental studies on volume load and on acute ischemia in open chest dogs-.1982 · 8 citations
  4. 4Pericardial modulation of right and left ventricular diastolic interaction.1981 · 59 citations
  5. 5Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs.1981 · 64 citations