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July 1, 1986

Right and left ventricular pressure-volume response to elevated pericardial pressure.

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Population

6 mongrel dogs (in vivo) and 5 postmortem hearts

Comparison

Infusion of 25, 50, and 75 ml of saline with… vs Control state (baseline before infusion)

Design

Preclinical

Authors

WSWilliam P. SantamoreRutgers, The State University of New JerseyJHJ. L. HeckmanTemple UniversityABA. A. BoveTemple University

Discussion

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Overview

Animal data link pericardial pressure to amplified ventricular interdependence; leaves open translation to human pericardial disease.

Structured PICO

P
Population
6 mongrel dogs (in vivo) and 5 postmortem hearts
I
Intervention
Infusion of 25, 50, and 75 ml of saline with dextran into the pericardial cavity to elevate pericardial pressure
C
Comparator
Control state (baseline before infusion)
O
Outcome
Right and left ventricular volumes and pressuressurrogate

Elevated pericardial pressure increases ventricular interdependence, such that smaller changes in right ventricular volume produce significantly greater changes in left ventricular volume.

Cite This Study

Santamore et al. (1986) studied this question.

synapsesocial.com/papers/6a910b1fc9591f682e830302https://doi.org/10.1164/arrd.1986.134.1.101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs.1981 · 64 citations
  2. 2Effects of increased pericardial pressure on the coupling between the ventricles1990 · 18 citations
  3. 3The effect of right ventricular filling on the pressure-volume relationship of ejecting canine left ventricle.1981 · 69 citations
  4. 4Extracardiac pressure and ventricular haemodynamics1987 · 3 citations
  5. 5Pericardial influences on ventricular filling in the conscious dog. An analysis based on pericardial pressure.1984 · 63 citations