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August 1, 1981Circulation ResearchOpen Access

The effect of right ventricular filling on the pressure-volume relationship of ejecting canine left ventricle.

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Why the study?

Does right ventricular filling affect the pressure-volume relationship of the left ventricle in an isolated canine heart model?

Population

Isolated cross-circulated ejecting canine heart preparation

Comparison

Varying right ventricular volumes vs Different right ventricular volumes, with and…

Design

Preclinical

Authors

WMW L MaughanGeneral CardiologyCKC H KallmanJohns Hopkins UniversityASArtin A. ShoukasJohns Hopkins University

Discussion

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Overview

RV-LV interdependence unlikely to produce large LV shifts except at supranormal RV volumes; leaves open pericardial effects in human pathophysiology.

Structured PICO

Does right ventricular filling affect the pressure-volume relationship of the left ventricle in an isolated canine heart model?

P
Population
Isolated cross-circulated ejecting canine heart preparation
I
Intervention
Varying right ventricular volumes
C
Comparator
Different right ventricular volumes, with and without the pericardium
O
Outcome
Left ventricular pressure-volume relationship (left ventricular pressure)surrogate

Ventricular interdependence is unlikely to lead to large acute pressure-volume shifts in the left ventricle except in the presence of considerably above normal right ventricular volumes.

Cite This Study

Maughan et al. (1981) studied this question.

synapsesocial.com/papers/6a703937e5469ee92be0fa53https://doi.org/10.1161/01.res.49.2.382
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Instantaneous pressure-volume relationship of the canine right ventricle.1979 · 315 citations
  2. 2Instantaneous Pressure-Volume Relationships and Their Ratio in the Excised, Supported Canine Left Ventricle1974 · 1,336 citations
  3. 3Left Ventricular Performance During By-Pass or Distension of the Right Ventricle1965 · 87 citations
  4. 4Left ventricular effects on right ventricular developed pressure1976 · 124 citations
  5. 5Volumes and Compliances Measured Simultaneously in the Right and Left Ventricles of the Dog1967 · 152 citations