Population
Male rats with severe myocardial infarction induced by coronary artery ligation or sham operation
Comparison
Coronary artery ligation (severe MI model) vs Sham operation
Design
Preclinical
Follow-up
8 months (35 weeks)
Authors
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Provides longitudinal rat post-MI model of decompensation; extends preclinical HF research but leaves open clinical translation.
The rat model of severe myocardial infarction demonstrates progressive cardiac decompensation, cardiac output redistribution, and terminal heart failure over an 8-month period.
DeFelice et al. (1989) studied this question.
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