Key result
In a rat model of myocardial infarction, left ventricular systolic and diastolic function significantly declined at 1, 2, and 4 weeks post-ligation compared to sham (P<0.05).
Population
Rat model of myocardial infarction induced by ligating the left anterior descending coronary artery
Comparison
Evaluation of cardiac function and pathological… vs Sham group
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports echocardiography for serial LV assessment in rat MI models; leaves open translation to human post-infarction monitoring.
p-value: p=<0.05
Echocardiography can accurately detect progressive changes in cardiac function and structure after myocardial infarction in rat models, providing a noninvasive evaluation tool for cardiovascular research.
Hu et al. (2012) studied Myocardial infarction (animal model). Myocardial infarction induction (LAD ligation) vs. Sham group was evaluated on Cardiac function (ejection fraction, fractional shortening, and ventricular dimensions) (p=<0.05). In a rat model of myocardial infarction, left ventricular systolic and diastolic function significantly declined at 1, 2, and 4 weeks post-ligation compared to sham (P<0.05).
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