Key result
In rats 3 weeks post-myocardial infarction, maximal extent of cell shortening at high extracellular calcium was significantly less in MI myocytes compared to sham (16% vs. 22%).
Population
Rats 3 weeks after ligation of left main coronary artery and isolated left ventricular myocytes
Comparison
Extracellular Ca2+ stimulation vs Sham-operated rat hearts and LV myocytes
Design
Preclinical
Follow-up
3 weeks
Authors
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Reduced Ca2+ responsiveness in post-MI myocytes may limit inotropic reserve; leaves open translation to human HF.
Absolute Event Rate: 16% vs 22%
Depressed LV function in post-MI hearts is driven by both cellular abnormalities in calcium handling and global structural changes.
Cheung et al. (1994) studied Myocardial infarction. Myocardial infarction (ligation of left main coronary artery) vs. Sham was evaluated on Maximal extent of cell shortening at [Ca2+]o of 4.9 mM. In rats 3 weeks post-myocardial infarction, maximal extent of cell shortening at high extracellular calcium was significantly less in MI myocytes compared to sham (16% vs. 22%).
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