December 2, 1997Circulation
Isolated Myocyte Contractile Function Is Normal in Postinfarct Remodeled Rat Heart With Systolic Dysfunction
Population
Rat model of myocardial infarction (infarcted and sham-operated rat hearts)
Comparison
Myocardial infarction vs Sham-operated rat hearts
Design
Preclinical
Follow-up
up to 6 weeks
Authors
Discussion
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Implication
Nonmyocyte factors may drive post-MI LV dysfunction in rats; hypothesis-generating for human validation before therapeutic targeting.
Structured PICO
P
Population
Rat model of myocardial infarction (infarcted and sham-operated rat hearts)
I
Intervention
Myocardial infarction
C
Comparator
Sham-operated rat hearts
O
Outcome
Global left ventricular (LV) structure and function, and structural and functional changes in isolated myocytes from the remote LV myocardiumsurrogate
In a rat model of postinfarction remodeling, isolated myocytes from the remote noninfarcted myocardium show normal contractile function despite significant structural lengthening, suggesting global LV dysfunction is driven by nonmyocyte factors.
Cite This Study
Anand et al. (1997) studied this question.