Why the study?
Does myocardial infarction-induced congestive heart failure alter sarcolemmal Na(+)-K(+)-ATPase activity in rats?
Population
Rat model of congestive heart failure induced by left ventricular coronary artery ligation
Comparison
Left ventricular coronary artery ligation vs Sham-operated animals
Design
Preclinical
Follow-up
16 weeks
Authors
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Late-onset Na(+)-K(+)-ATPase depression in uninfarcted rat LV post-MI may mark HF progression; leaves open translational relevance to human myocardium.
Does myocardial infarction-induced congestive heart failure alter sarcolemmal Na(+)-K(+)-ATPase activity in rats?
In a rat model of post-myocardial infarction heart failure, sarcolemmal Na(+)-K(+)-ATPase activity is depressed at 8 and 16 weeks, suggesting an adaptive mechanism during the development of congestive heart failure.
Dixon et al. (1992) studied this question.
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