Key result
In a rat model of myocardial infarction, the density of Ca2+ receptors/channels was decreased in the uninfarcted experimental left ventricle at 8 and 16 weeks compared to sham-operated controls.
Why the study?
Does myocardial infarction-induced congestive heart failure alter the density of Ca2+ receptors/channels in rat hearts?
Does myocardial infarction-induced congestive heart failure alter the density of Ca2+ receptors/channels in rat hearts?
Congestive heart failure following myocardial infarction in rats is associated with a decreased density of Ca2+ channels in the uninfarcted left ventricle, potentially contributing to depressed contractile function.
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Hypothesis-generating for Ca2+ channel remodeling in post-MI HF; leaves open human relevance and clinical translation.
Dixon et al. (1990) studied Congestive heart failure due to myocardial infarction. Left coronary artery ligation (myocardial infarction) vs. Sham-operated animals was evaluated on Density of Ca2+ receptors/channels in crude membranes assessed by [3H]nitrendipine binding assay. In a rat model of myocardial infarction, the density of Ca2+ receptors/channels was decreased in the uninfarcted experimental left ventricle at 8 and 16 weeks compared to sham-operated controls.
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