Population
Rats with congestive heart failure induced by left coronary artery ligation
Comparison
Left coronary artery ligation vs Sham-operated animals
Design
Preclinical
Follow-up
4, 8, and 16 weeks
Authors
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May underlie contractile impairment in post-MI remodeling; hypothesis-generating for Na(+)-Ca2+ exchanger modulation in heart failure.
In a rat model of post-MI heart failure, depressed sarcolemmal Na(+)-dependent Ca2+ uptake is associated with contractile abnormalities, while ATP-dependent Ca2+ pump activity remains unchanged.
Dixon et al. (1992) studied this question.
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