Population
Rats subjected to aortic banding for 28 days and 22-wk-old spontaneously hypertensive rats
Comparison
Pressure overload via aortic banding or… vs Sham-operated rats or control preparations
Design
Preclinical
Follow-up
28 days (aortic banding model)
Authors
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Altered Ca2+ transport in pressure-overload hypertrophy may be adaptive; this Level 5 animal finding leaves open relevance to human HF progression.
Cardiac hypertrophy induced by pressure overload leads to alterations in sarcolemmal Ca2+ transport activities, potentially serving as an adaptive mechanism for Ca2+ removal from myocardial cells.
Nakanishi et al. (1989) studied this question.
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