Key result
Cardiac overload in rats decreased the Ca2+ uptake rate, phosphorylated intermediate of Ca(2+)-ATPase, and Ca(2+)-ATPase mRNA as a function of relative left ventricular weight increase.
Population
53 rats (34 subjected to cardiac overload and 19 sham-operated animals)
Comparison
Cardiac overload model (hypertrophy) vs Sham-operated animals
Design
Preclinical
Authors
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May impair relaxation in hypertrophied myocardium; hypothesis-generating in rats and leaves open human relevance.
Cardiac hypertrophy in rats leads to a quantitative decrease in Ca2+-ATPase protein and mRNA, reducing the Ca2+ pump activity of the sarcoplasmic reticulum.
Levitsky et al. (1991) studied Cardiac hypertrophy (n=53). Cardiac overload vs. Sham operation was evaluated on Oxalate-supported Ca2+ uptake rate, steady-state level of phosphorylated intermediate of Ca(2+)-ATPase, and amount of Ca(2+)-ATPase mRNA. Cardiac overload in rats decreased the Ca2+ uptake rate, phosphorylated intermediate of Ca(2+)-ATPase, and Ca(2+)-ATPase mRNA as a function of relative left ventricular weight increase.
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