Why the study?
Does nicardipine improve mechanical recovery and reduce tissue injury in isolated perfused rat hearts subjected to ischemia?
Population
Isolated perfused rat heart (Langendorff preparation)
Comparison
Nicardipine added to perfusate 5 min prior to… vs Ischemia without nicardipine
Design
Preclinical
Follow-up
20 to 30 minutes of ischemia followed by reperfusion
Authors
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No immediate clinical implications for ischemia; leaves open translation of nicardipine protection beyond this rat heart model.
Does nicardipine improve mechanical recovery and reduce tissue injury in isolated perfused rat hearts subjected to ischemia?
Nicardipine protects against ischemic mechanical failure and tissue injury in isolated rat hearts, likely by inhibiting calcium influx during reperfusion.
Shikama et al. (1985) studied this question.
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