Key result
Nicardipine therapy linked to reduced systemic vascular resistance and increased cardiac index at rest and exercise.
Why the study?
Does oral nicardipine improve rest and exercise hemodynamics in patients with severe, chronic congestive heart failure?
Population
10 patients with severe, chronic congestive heart failure
Comparison
Oral nicardipine therapy for 1 week vs Baseline state (before therapy)
Design
Case_series
Follow-up
1 week
Authors
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Hypothesis-generating for nicardipine in severe HF; larger randomized trials needed before any practice consideration.
Does oral nicardipine improve rest and exercise hemodynamics in patients with severe, chronic congestive heart failure?
Nicardipine-mediated vasodilation significantly improves both rest and exercise cardiac performance in patients with severe chronic congestive heart failure without causing negative inotropic effects or reflex sympathetic activation.
Ryman et al. (1986) studied severe, chronic congestive heart failure (n=10). nicardipine vs. baseline was evaluated on Rest and exercise hemodynamics. Nicardipine therapy significantly reduced systemic arterial pressure and vascular resistance, and increased cardiac index and stroke volume index at rest and during exercise.