September 1, 1982Journal of Cardiovascular Pharmacology
Influence of Nicardipine on the Blood Pressure at Rest and on the Pressor Responses to Cold, Isometric Exertion, and Dynamic Exercise in Hypertensive Patients
Why the study?
Does nicardipine reduce resting blood pressure and pressor responses to physical stimuli in male patients with stable uncomplicated essential hypertension?
Population
n=6 male patients with stable uncomplicated essential hypertension
Comparison
Nicardipine administered orally in doses of 5… vs Placebo
Design
Other, single-blind
Follow-up
1 week per dose period
Authors
Discussion
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Member takes
Implication
May support nicardipine in active hypertensive patients without exercise pressor blunting; leaves open confirmation in larger randomized trials.
Structured PICO
Does nicardipine reduce resting blood pressure and pressor responses to physical stimuli in male patients with stable uncomplicated essential hypertension?
P
Population
n=6 male patients with stable uncomplicated essential hypertension
I
Intervention
Nicardipine administered orally in doses of 5 mg, 10 mg, 20 mg, and 20 mg each given three times daily consecutively for 1 week per dose period
C
Comparator
Placebo
O
Outcome
Blood pressure and heart rate at rest and during three pressor stimuli (skin cold, isometric exertion, and dynamic exercise) measured at the end of each dose periodsurrogate
Nicardipine effectively lowers resting diastolic blood pressure through vasodilation without impairing sympathetic postural control or pressor responses to exercise.
Cite This Study
Taylor et al. (1982) studied this question.