Why the study?
Does nicardipine reduce blood pressure and alter reflex cardiac control in untreated patients with essential hypertension?
Population
8 untreated patients with essential hypertension
Comparison
Nicardipine hydrochloride vs Control period (baseline)
Design
Cohort
Follow-up
2 months
Authors
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Supports nicardipine-associated BP reduction without tachycardia in hypertension; leaves open baroreflex resetting effects pending randomized trials.
Does nicardipine reduce blood pressure and alter reflex cardiac control in untreated patients with essential hypertension?
Nicardipine significantly reduces intra-arterial blood pressure in essential hypertension without causing chronic reflex tachycardia due to resetting of the baroreflex control mechanism.
Littler et al. (1985) studied this question.
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